AMG-3 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of ÃÂ<sup>8</sup>-THC substituted with a dithiolane group on the 3-position side chain. AMG-3 is a potent agonist at both CB<sub>1</sub> and CB<sub>2</sub> receptors with a K<sub>i</sub> of 0.32 nM at CB<sub>1</sub> and 0.52 nM at CB<sub>2</sub>, and its particularly high binding affinity has led to it being used as a template for further structural development of novel cannabinoid drugs. It has sedative and analgesic effects, with analgesia lasting for up to 36 hours after administration.