AM-411 (part of the AM cannabinoid series) is an analgesic drug that is a cannabinoid agonist. It is a derivative of ÃÂ8-THC substituted with an adamantyl group at the 3-position, demonstrating that the binding pocket for the alkyl chain at this position can accommodate significant bulk.
AM-411 is a potent and fairly selective CB<sub>1</sub> full agonist with a K<sub>i</sub> of 6.80 nM, but is still also a moderately potent CB<sub>2</sub> agonist with a K<sub>i</sub> of 52.0 nM. It produces similar effects to other cannabinoid agonists such as analgesia, sedation, and anxiolysis.