In enzymology, an ADP-specific glucokinase () also known as ADP-dependent glucokinase is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are ADP and D-glucose, whereas its two products are AMP and D-glucose 6-phosphate.
This enzyme belongs to the family of transferases, to be specific those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor.
In humans, the ADP-dependent glucokinase is encoded by the ADPGK gene.
Examples of the ADP-dependent glucokinase structure solved by x-ray crystallography include the enzyme from mouse PDB accession code 5CCF and Archaea .