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ADP-ribosylhydrolase 1

(ADP-ribosyl)hydrolase 1, also termed [Protein ADP-ribosylarginine] hydrolase and protein-N<sup>ω</sup>-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase (), is an enzyme that in humans is encoded by the ADPRH gene. This enzyme is a specific mono(ADP-ribosyl)hydrolase that catalyses the removal of an ADP-ribosyl modification from target arginine residues of protein substrates. The chemical reactions can formally be described as follows:

N<sup>ω</sup>-(ADP-<small>D</small>-ribosyl)-L-arginyl-[protein] + H<sub>2</sub>O ADP-<small>D</small>-ribose + L-arginyl-[protein]
In addition, the enzyme can reverse the ADP-ribosylation of free arginine:
N<sup>ω</sup>-(ADP-<small>D</small>-ribosyl)-L-arginine + H<sub>2</sub>O ADP-<small>D</small>-ribose + L-arginine

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