AC927 or 1-(2-phenylethyl)piperidine is a selective sigma receptor antagonist, with reported binding affinity of K<sub>i</sub> = 30 ñ 2 nM for the sigma-1 receptor and K<sub>i</sub> = 138 ñ 18 nM for the sigma-2 receptor, and negligible binding affinity for other major central nervous system receptors, transporters, and ion channels.
AC927 is reported to attenuate the locomotor stimulation induced by methamphetamine in mice.