In enzymology, a 8-oxocoformycin reductase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are coformycin and NADP<sup>+</sup>, whereas its 3 products are 8-oxocoformycin, NADPH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is coformycin:NADP<sup>+</sup> 8-oxidoreductase. This enzyme is also called 8-ketodeoxycoformycin reductase.