8-OH-DPAT, also known as 8-hydroxy-2-(dipropylamino)tetralin, is a serotonin 5-HT<sub>1A</sub> receptor agonist of the 2-aminotetralin family which was developed in the 1980s and has been widely used to study the function of the 5-HT<sub>1A</sub> receptor. It was one of the first major 5-HT<sub>1A</sub> receptor full agonists to have been discovered.
Originally believed to be selective for the 5-HT<sub>1A</sub> receptor, 8-OH-DPAT was later found to act as a serotonin 5-HT<sub>7</sub> receptor agonist and serotonin reuptake inhibitor or releasing agent as well.
In animal studies, 8-OH-DPAT has been shown to possess antidepressant, anxiolytic, serenic (antiaggressive), anorectic, antiemetic, hypothermic, hypotensive, bradycardic, hyperventilative, and analgesic effects.