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7beta-hydroxysteroid dehydrogenase (NADP+)

In enzymology, a 7beta-hydroxysteroid dehydrogenase (NADP<sup>+</sup>) () is an enzyme that catalyzes the chemical reaction

a 7beta-hydroxysteroid + NADP<sup>+</sup> a 7-oxosteroid + NADPH + H<sup>+</sup>

Thus, the two substrates of this enzyme are 7beta-hydroxysteroid and NADP<sup>+</sup>, whereas its 3 products are 7-oxosteroid, NADPH, and H<sup>+</sup>.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is 7beta-hydroxysteroid:NADP<sup>+</sup> 7-oxidoreductase. Other names in common use include NADP<sup>+</sup>-dependent 7beta-hydroxysteroid dehydrogenase, and 7beta-hydroxysteroid dehydrogenase (NADP<sup>+</sup>).

References