6-Methyl-DMT, or 6-Me-DMT, also known as 6-methyl-N,N-dimethyltryptamine or as 6,N,N-trimethyltryptamine (6,N,N-TMT or 6-TMT), is a serotonin receptor modulator of the tryptamine family related to dimethyltryptamine (DMT). It is the 6-methyl derivative of DMT.
6-Methyl-DMT was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).
6-Methyl-DMT showed about half the affinity of DMT for the ketanserin-labeled serotonin 5-HT<sub>2</sub> receptor (K<sub>i</sub> = 2,500nM and 1,200nM, respectively). The drug did not substitute for 5-MeO-DMT in rodent drug discrimination tests. According to David E. Nichols, 6-substituted tryptamines in general may be inactive as serotonergic psychedelics. However, 6-fluoro-AMT is known to be robustly active as a psychedelic.
The chemical synthesis of 6-methyl-DMT has been described.
Analogues of 6-methyl-DMT include dimethyltryptamine (DMT), 6-MeO-DMT, 6-MeO-DiPT, 6-MeO-MiPT, 6-hydroxy-DMT, 6-hydroxy-DET, 6-fluoro-DMT, 6-fluoro-DET, 6-fluoro-AMT, O-4310 (1-iPr-6-F-4-HO-DMT), 1-methyl-DMT, 2-methyl-DMT, 4-methyl-DMT, 5-methyl-DMT, and 7-methyl-DMT, among others.
6-Methyl-DMT was first described in the scientific literature by Richard Glennon and colleagues by 1980.