5F-ADB-PINACA is a cannabinoid designer drug that is an ingredient in some synthetic cannabis products. It is a potent agonist of the CB<sub>1</sub> receptor and CB<sub>2</sub> receptor with EC<sub>50</sub> values of 0.24 nM and 2.1 nM respectively.
Twelve 5F-ADB-PINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Major metabolic reactions included oxidative defluorination followed by carboxylation.
5F-ADB-PINACA is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.