5-MeS-DMT, also known as 5-methylthio-N,N-dimethyltryptamine or as 5-methylthio-DMT, is a lesser-known psychedelic drug of the tryptamine family. It is the 5-methylthio derivative of dimethyltryptamine (DMT) and is an analogue of 5-MeO-DMT.
In his book TiHKAL (Tryptamines I Have Known and Loved), Alexander Shulgin lists the dose as 15 to 30mg smoked and its duration as less than 1hour. In individual reports, the duration was 10 to 30minutes. The effects included feeling stoned and no visuals, among others. It was also described as coming on very fast and being quite intense. The drug is described as being about half as potent as 5-MeO-DMT.
5-MeS-DMT was less potent than 5-MeO-DMT and psilocin (4-HO-DMT) but more potent than 4-MeO-DMT or 4-MeS-DMT in rodent behavioral studies.
The chemical synthesis of 5-MeS-DMT has been described.
Analogues of 5-MeS-DMT include dimethyltryptamine (DMT), 5-MeO-DMT, and 5,N,N-TMT (5-methyl-DMT; 5-Me-DMT), among others.
It was first described in the scientific literature by Richard Glennon and colleagues by 1982. However, 5-MeS-DMT was synthesized and tested by Shulgin as early as 1979.