5-MeO-PiPT, also known as 5-methoxy-N-propyl-N-isopropyltryptamine, is a substituted tryptamine derivative which is claimed to have psychedelic effects. It has been sold as a designer drug, first being identified in 2021 in British Columbia, Canada.
5-MeO-PiPT was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).
5-MeO-PiPT acts as a serotonin 5-HT<sub>1A</sub> and 5-HT<sub>2A</sub> receptor agonist, with an of 13.8nM and an efficacy of 89%.
Analogues of 5-MeO-PiPT include propylisopropyltryptamine (PiPT), 4-HO-PiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MeO-DiPT, 5-MeO-MiPT, 5-MeO-EiPT, and 5-MeO-iPALT (ASR-3001), among others.