5-Allyloxy-AMT

5-Allyloxy-AMT, also known as 5-allyloxy-α-methyltryptamine, is a serotonin 5-HT₂ receptor agonist of the tryptamine, 5-alkyloxytryptamine, and α-alkyltryptamine families.

It is known to act as high-efficacy partial agonist or near-full agonist of the serotonin 5-HT_2A receptor ( = 162nM; = 89%) and of the serotonin 5-HT_2B receptor ( = 60nM; = 82%), whereas activity at the serotonin 5-HT_2C receptor and other serotonin receptors was not reported.

5-Allyloxy-AMT was the most potent serotonin 5-HT_2A receptor agonist reported in a large series of tryptamines that was evaluated in search of potent and selective serotonin 5-HT_2B receptor agonists. The only exceptions were the reference serotonin 5-HT_2A receptor agonists serotonin (5-HO-T) ( = 79nM; = 100%) and (S)-α-methylserotonin ((S)-αMS) ( = 54nM; = 103%).

See also

• 5-Ethoxy-AMT
• 5-Ethoxy-DMT
• 5-Methoxy-AMT
• 5-(Nonyloxy)tryptamine
• 5-Benzyloxytryptamine
• BW-723C86

References

External links

• 5-Allyloxy-AMT - Isomer Design