4-Methylephedrine (4-ME), also known as dihydromephedrone (DHMMC) or as ò-hydroxy-4-methylmethamphetamine, is a putative stimulant drug of the phenethylamine, amphetamine, and ò-hydroxyamphetamine families. It is the ò-hydroxy analogue of mephedrone and is a known metabolite of mephedrone. The drug acts as a monoamine reuptake inhibitor and monoamine releasing agent, albeit with relatively low potency and far less than that of mephedrone.
4-Methylephedrine acts as a monoamine reuptake inhibitor and monoamine releasing agent in vitro, with potency far lower than that of its parent drug mephedrone.
The drug is a weak reuptake inhibitor of norepinephrine, dopamine, and serotonin, with values of 64.98üM, 23.97üM, and 23.53üM for the serotonin, norepinephrine, and dopamine transporters, respectively. The values for individual enantiomers of 4-methylephedrine have also been reported. In addition, data for induction of monoamine release in the HEK293 system have been reported.