In enzymology, a 4-hydroxyphenylpyruvate oxidase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are 4-hydroxyphenylpyruvate and O<sub>2</sub>, whereas its two products are 4-hydroxyphenylacetate and CO<sub>2</sub>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. The systematic name of this enzyme class is 4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating). This enzyme participates in tyrosine metabolism.