Trans-cinnamate 4-monooxygenase

In enzymology, a trans-cinnamate 4-monooxygenase () is an enzyme that catalyzes the chemical reaction

The 4 substrates of this enzyme are trans-cinnamate, NADPH, H⁺, and O₂, whereas its 3 products are 4-hydroxycinnamate, NADP⁺, and H₂O. This enzyme participates in phenylalanine metabolism and phenylpropanoid biosynthesis. It employs one cofactor, heme.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor.

Nomenclature

The systematic name of this enzyme class is trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating). Other names in common use include:

• cinnamic acid 4-hydroxylase,
• oxygenase, cinnamate 4-mono-,
• CA4H (gene name),
• CYP73A1 (gene name),
• cytochrome P450 cinnamate 4-hydroxylase,
• cinnamate 4-hydroxylase,
• cinnamate 4-monooxygenase,
• cinnamate hydroxylase,
• cinnamic 4-hydroxylase,
• cinnamic acid 4-monooxygenase,
• cinnamic acid p-hydroxylase,
• hydroxylase, cinnamate 4-,
• t-cinnamic acid hydroxylase,
• trans-cinnamate 4-hydroxylase, and
• trans-cinnamic acid 4-hydroxylase.

References

Further reading