In enzymology, a 4-hydroxycyclohexanecarboxylate dehydrogenase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are trans-4-hydroxycyclohexanecarboxylate and NAD<sup>+</sup>, whereas its 3 products are 4-oxocyclohexanecarboxylate, NADH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is trans-4-hydroxycyclohexanecarboxylate:NAD<sup>+</sup> 4-oxidoreductase. This enzyme is also called trans-4-hydroxycyclohexanecarboxylate dehydrogenase.