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4-Fluoronitrobenzene

4-Fluoronitrobenzene is an organic compound with the formula FC<sub>6</sub>H<sub>4</sub>NO<sub>2</sub>. It is one of three isomeric fluoronitrobenzenes. A yellow oil, it is prepared from 4-nitrochlorobenzene using the Halex process:

4-Fluoronitrobenzene can be hydrogenated to give 4-fluoroaniline, which is a precursor to the fungicide and parafluorofentanyl.

Owing to the presence of the electron withdrawing nitro group, the fluoride is a good leaving group in fluoronitrobenzenes. Thus reaction with phenoxide gives the mononitrodiphenylether.

Applications

  1. U-41792
  2. B777-81
  3. WAY-213,613
  4. Butacetin
  5. Cerlapirdine

References