In enzymology, a 4-cresol dehydrogenase (hydroxylating) () is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are 4-cresol, acceptor, and H<sub>2</sub>O, whereas its two products are 4-hydroxybenzaldehyde and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH<sub>2</sub> groups with other acceptors. The systematic name of this enzyme class is 4-cresol:acceptor oxidoreductase (methyl-hydroxylating). Other names in common use include p-cresolâÂÂ(acceptor) oxidoreductase (hydroxylating), and p-cresol methylhydroxylase. This enzyme participates in toluene and xylene degradation. It has 2 cofactors: FAD, and Cytochrome c.
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes , , , and .