4-AcO-MPT, also known as 4-acetoxy-N-methyl-N-propyltryptamine, is a psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to 4-AcO-DMT (psilacetin).
4-AcO-MPT is thought to act as a prodrug of 4-HO-MPT and hence is believed to act as a non-selective serotonin receptor agonist including of the serotonin 5-HT<sub>2A</sub> receptor. The receptor interactions of 4-AcO-MPT have been studied. The drug produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents,
Analogues of 4-AcO-MPT include methylpropyltryptamine (MPT), 4-HO-MPT (meprocin), 5-MeO-MPT, 4-AcO-DMT (psilacetin), 4-AcO-MET (metacetin), 4-AcO-MiPT (mipracetin), and 4-AcO-DPT (depracetin), among others.
4-AcO-MPT was first described in the scientific literature by at least 2017. It was first encountered as a novel designer drug in 2018.
4-AcO-MPT is not a controlled substance in Canada as of 2025.
4-AcO-MPT is a controlled substance in Sweden.