3alpha-hydroxysteroid dehydrogenase (A-specific)

In enzymology, a 3alpha-hydroxysteroid dehydrogenase (A-specific) () is an enzyme that catalyzes the chemical reaction

The 3 substrates of this enzyme are androsterone, NAD⁺, and NADP⁺, whereas its 4 products are 5alpha-androstane-3,17-dione, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor, more specifically it is part of the group of hydroxysteroid dehydrogenases. The systematic name of this enzyme class is 3alpha-hydroxysteroid:NAD(P)⁺ oxidoreductase (A-specific).

Structural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , and .

References