In enzymology, a 3alpha-hydroxyglycyrrhetinate dehydrogenase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are 3alpha-hydroxyglycyrrhetinate and NADP<sup>+</sup>, whereas its 3 products are 3-oxoglycyrrhetinate, NADPH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is 3alpha-hydroxyglycyrrhetinate:NADP<sup>+</sup> 3-oxidoreductase.