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3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase

In enzymology, a 3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase is an enzyme that catalyzes the chemical reaction:

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + NAD<sup>+</sup> + H<sub>2</sub>O (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + NADH + 2 H<sup>+</sup>

The 3 substrates of this enzyme are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, NAD<sup>+</sup>, and H<sub>2</sub>O, whereas its 2 products are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate, NADH, and H<sup>+</sup>. This enzyme participates in bile acid biosynthesis.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase. Other names in common use include:

  • cholestanetriol-26-al 26-dehydrogenase,
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, dehydrogenase,
  • trihydroxydeoxycoprostanal dehydrogenase,
  • THAL-NAD oxidoreductase,
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+, and
  • 26-oxidoreductase.

References