The enzyme 3-hydroxybutyryl-CoA dehydratase () catalyzes the chemical reaction
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming). Other names in common use include <small>D</small>-3-hydroxybutyryl coenzyme A dehydratase, <small>D</small>-3-hydroxybutyryl-CoA dehydratase, enoyl coenzyme A hydrase (<small>D</small>), and (3R)-3-hydroxybutanoyl-CoA hydro-lyase. This enzyme participates in butanoate metabolism.