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3-chloro-D-alanine dehydrochlorinase

The enzyme 3-chloro-<small>D</small>-alanine dehydrochlorinase (EC 4.5.1.2) catalyzes the reaction

3-chloro-<small>D</small>-alanine + H<sub>2</sub>O = pyruvate + chloride + NH<sub>3</sub> (overall reaction)
:(1a) 3-chloro-<small>D</small>-alanine = chloride + 2-aminoprop-2-enoate
:(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous)
:(1c) 2-iminopropanoate + H<sub>2</sub>O = pyruvate + NH<sub>3</sub> (spontaneous)

This enzyme belongs to the family of lyases, specifically the class of carbon-halide lyases. The systematic name of this enzyme class is 3-chloro-<small>D</small>-alanine chloride-lyase (deaminating; pyruvate-forming). Other names in common use include β-chloro-<small>D</small>-alanine dehydrochlorinase, and 3-chloro-<small>D</small>-alanine chloride-lyase (deaminating). It employs one cofactor, pyridoxal phosphate.

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