Methylcrotonyl-CoA

3-Methylcrotonyl-CoA (β-Methylcrotonyl-CoA or MC-CoA) is an intermediate in the metabolism of leucine.

It is found in mitochondria, where it is formed from isovaleryl-coenzyme A by isovaleryl coenzyme A dehydrogenase. It then reacts with CO₂ to yield 3-methylglutaconyl-CoA, catalysed by 3-Methylcrotonyl-CoA carboxylase.

Leucine metabolism

See also

• Methylcrotonyl-CoA carboxylase

References