3-Bromocytisine

3-Bromocytisine is a derivative of the toxic alkaloid cytisine that acts as a highly potent agonist at neural nicotinic acetylcholine receptors, binding primarily to the α₄β₂ and α₇ subtypes. 3-Bromocytisine is a full agonist at the α₇ subtype while it is only a partial agonist at α₄β₂, but has an extremely strong binding affinity at α₄β₂ with 200-fold selectivity for α₄β₂ over α₇. In animal studies 3-bromocytisine stimulates the release of dopamine and noradrenaline and increases locomotor activity.

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