2CD-5EtO, also known as 5-ethoxy-2-methoxy-4-methylphenethylamine, is a psychedelic drug of the phenethylamine, 2C, and TWEETIO families related to 2C-D. It is the analogue of 2C-D in which the methoxy group at the 5 position has been extended to an ethoxy group.
In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 2CD-5EtO's dose as 40 to 50mg orally, its onset as slow and gradual, its time to peak or full effects as about 2hours, and its duration as 12hours. The effects of 2CD-5EtO were said to include being "largely free from excitement", having "a friendly openness and outgoingness that allowed easy talk, interaction, humor", and allowing for healthy appetite.
The chemical synthesis of 2CD-5EtO has been described.
2CD-5EtO was first described in the literature by Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) in 1991. It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin.
2CD-5EtO is a controlled substance in Canada under phenethylamine blanket-ban language.