27S pre-rRNA (guanosine<sup>2922</sup>-2'-O)-methyltransferase (, Spb1p (gene), YCL054W (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:27S pre-rRNA (guanosine<sup>2922</sup>-2'-O-)-methyltransferase. This enzyme catalyses the following chemical reaction
Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922.