The 25th Annual D.I.C.E. Awards was the 25th edition of the D.I.C.E. Awards ("Design Innovate Communicate Entertain"), an annual awards event that honored the best games in the video game industry during 2021. The awards were arranged by the Academy of Interactive Arts & Sciences (AIAS). The nominees were announced on January 13, 2022. It was also held as part of the Academy's 2022 D.I.C.E. Summit, and was co-hosted by Jessica Chobot of Nerdist News, and Kinda Funny co-founder Greg Miller. The winners were announced in a ceremony at the Mandalay Bay Resort in Las Vegas on .
' received the most nominations, and won the most awards, while It Takes Two won "Game of the Year". Sony Interactive Entertainment was the most nominated and award-winning publisher with Insomniac Games as the most nominated and award-winning developer. Electronic Arts and Nintendo had the most nominated games while Xbox Game Studios had the most award-winning games.
Ed Boon, co-creator of the Mortal Kombat franchise, was inducted into the Academy's Hall of Fame. Phil Spencer, CEO of Microsoft Gaming and head of Xbox Game Studios, received the "Lifetime Achievement Award".
Winners are listed first, highlighted in boldface, and indicated with a double dagger ().