25N-N1-Nap is a phenethylamine derivative from the 25-NB class, which acts as a potent agonist at the 5-HT<sub>2A</sub> receptor with weaker activity at 5-HT<sub>2B</sub> and 5-HT<sub>2C</sub>. 25N-N1-Nap is a biased agonist, producing robust activation of 5-HT<sub>2A</sub> coupled signaling pathways mediated by beta arrestin 2, but with little or no activation of pathways mediated via G<sub>q</sub>. In animal studies it produces antipsychotic-like effects but without producing the head-twitch response associated with psychedelic activity.