25F-NBOMe, also known as 2C-F-NBOMe or NBOMe-2C-F as well as N-(2-methoxybenzyl)-4-fluoro-2,5-dimethoxyphenethylamine, is a serotonin 5-HT<sub>2</sub> receptor agonist and possible serotonergic psychedelic of the phenethylamine, 2C, and 25-NB (NBOMe) families. It is the NBOMe (N-(2-methoxybenzyl)) derivative of 2C-F.
25F-NBOMe acts as a potent agonist of the serotonin 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> receptors and also shows interactions with certain other targets, such as the serotonin 5-HT<sub>2B</sub> receptor. However, it shows more than an order of magnitude lower potency as a serotonin 5-HT<sub>2A</sub> receptor agonist than certain other NBOMe drugs like 25I-NBOMe and 25B-NBOMe in vitro.
25F-NBOMe was first described in the scientific literature by 2010.
25F-NBOMe is a controlled substance in Canada under phenethylamine blanket-ban language.