23S rRNA pseudouridine<sup>746</sup> synthase (, RluA, 23S RNA PSI<sup>746</sup> synthase, 23S rRNA pseudouridine synthase, pseudouridine synthase RluA) is an enzyme with systematic name 23S rRNA-uridine<sup>746</sup> uracil mutase. This enzyme catalyses the following chemical reaction
RluA is the only protein responsible for the in vivo formation of 23S RNA pseudouridine<sup>746</sup>.