23S rRNA pseudouridine<sup>2457</sup> synthase (, RluE, YmfC) is an enzyme with systematic name 23S rRNA-uridine<sup>2457</sup> uracil mutase. This enzyme catalyses the following chemical reaction
The enzyme modifies uridine<sup>2457</sup> in a stem of 23S rRNA in Escherichia coli.