23S rRNA (cytidine<sup>1920</sup>-2'-O)-methyltransferase (, TlyA) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (cytidine<sup>1920</sup>-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction
This is a bifunctional enzyme from Mycobacterium tuberculosis.