23S rRNA (adenine<sup>2503</sup>-C<sup>8</sup>)-methyltransferase (, Cfr (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenine<sup>2503</sup>-C<sup>8</sup>)-methyltransferase. This enzyme catalyses the following chemical reaction
This enzyme is a member of the 'AdoMet radical' (radical SAM) family.