The 221st Coastal Division () was an infantry division of the Royal Italian Army during World War II. Royal Italian Army coastal divisions were second line divisions formed with reservists and equipped with second rate materiel. They were often commanded by officers called out of retirement.
The division was activated on 15 April 1942 in Latina by uniting the two coastal defense sectors "Littoria" and "Gaeta". The division was assigned to XVII Army Corps and based its headquarter in Pontinia. The division was responsible for the coastal defense of the coast of southern Lazio between the rivers Astura and Garigliano.
After the announcement of the Armistice of Cassibile on 8 September 1943, the division was disbanded by invading German forces.
If needed the artillery for the division would come from the following artillery schools located within the division's area of responsibility:
The division's commanding officers were: