21S rRNA (uridine<sup>2791</sup>-2'-O)-methyltransferase (, MRM2 (gene), mitochondrial 21S rRNA methyltransferase, mitochondrial rRNA MTase 2) is an enzyme with systematic name S-adenosyl-L-methionine:21S rRNA (uridine<sup>2791</sup>-2'-O-)-methyltransferase. This enzyme catalyses the following chemical reaction
The enzyme catalyses the methylation of uridine<sup>2791</sup> of mitochondrial 21S rRNA.