The 2025 Wyoming Cowboys football team represented the University of Wyoming as a member of the Mountain West Conference (MW) during the 2025 NCAA Division I FBS football season. Led by second-year head coach Jay Sawvel, the Cowboys played home games on campus, at War Memorial Stadium in Laramie, Wyoming.
The Wyoming Cowboys drew an average home attendance of 23,433, the highest of all American football teams from Wyoming.
The Mountain West's preseason media poll was released on July 16, 2025. Wyoming was predicted to finished tenth in the conference.
Wyoming signed a high school class of 24 scholarship athletes.