The 2025 Winston-Salem Open was a men's tennis tournament played on outdoor hard courts. It was the 56th edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and an ATP 250 tournament on the 2025 ATP Tour. It took place at Wake Forest University in Winston-Salem, North Carolina, United States, from August 17 to August 23, 2025.
<sup>â </sup> Rankings are as of August 4, 2025.
The following players received wildcards into the singles main draw:
The following player received entry using a protected ranking:
The following player received entry as an emergency substitution:
The following player received entry as a late entry:
The following players received entry from the qualifying draw:
<sup>â </sup> Rankings are as of August 4, 2025.
The following pairs received wildcard entry into the doubles main draw :