The 2025 Vancouver Whitecaps FC season was the club's fifteenth season in Major League Soccer, the top division of soccer in the United States and Canada. Including previous iterations of the franchise, this was the 48th season of professional soccer being played in Vancouver under a variation of the "Whitecaps" name.
Having won the 2024 Canadian Championship, the Whitecaps participated in the CONCACAF Champions Cup for a third consecutive season and fifth time overall. The club advanced to the final, where they were defeated by Liga MX side Cruz Azul, finishing as runner-up. The Whitecaps also participated in the 2025 Canadian Championship, winning their fourth domestic cup championship in a row. On January 28, MLS announced that all teams would participate in at least one but no more than two cup competitions. Due to their participation in the Canadian Championship and CONCACAF Champions Cup, the Whitecaps did not participate in the 2025 Leagues Cup.
On November 25, 2024, the Whitecaps parted ways with head coach Vanni Sartini. On January 14, 2025, the Whitecaps announced that they had hired Jesper Sørensen as their new head coach.
On August 6, 2025, the Whitecaps gained international attention due to the signing of German superstar and 2014 FIFA World Cup winner Thomas Müller in free agency after a storied 17-season club career at Bayern Munich, being a key centrepiece towards the team's multiple trophies. The signing helped boost morale for the team, as from Müller's debut with the Whitecaps on August 17, 2025, until the final regular season match of the season in a 1-2 loss to FC Dallas at home, the Whitecaps went on a ten game unbeaten streak in all competitions, including a MLS-era record of a postseason-clinching 7-0 win over the eventual Supporters' Shield winners Philadelphia Union on September 13, 2025, which is tied for the largest margin of victory in the 2025 Major League Soccer season. The Whitecaps finished the regular season with a MLS-era record 63 points; however, they did not win the Western Conference in the regular season due to losing a tiebreaker with San Diego FC, as the latter won one more game than the Whitecaps. However, the Whitecaps would eventually win their first Western Conference title against San Diego in the MLS Cup playoffs to advance to their first MLS Cup game in its MLS-era club history, where they would lose to Inter Miami 1-3.
Whitecaps FC confirmed their preseason schedule on January 15, 2025.
As champions of the 2024 tournament, the Whitecaps received a bye into the quarter-finals.
While Vancouver Whitecaps FC qualified for the 2025 Leagues Cup as one of the top 9 teams in the Western Conference for the 2024 season, they were already capped on their two continental competitions they could participate in (2025 Canadian Championship and 2025 CONCACAF Champions Cup) and instead gave their spot to expansion team San Diego FC.
|- ! colspan="16" style=background:#dcdcdc; text-align:center| Goalkeepers
|- ! colspan="16" style=background:#dcdcdc; text-align:center| Defenders
|- ! colspan="16" style=background:#dcdcdc; text-align:center| Midfielders
|- ! colspan="16" style=background:#dcdcdc; text-align:center| Forwards
|- ! colspan="16" style=background:#dcdcdc; text-align:center| Players transferred out during the season