The 2025 Tre Valli Varesine was the 104th edition of the Tre Valli Varesine road cycling one day race, which was held from Busto Arsizio to Legnano, Italy, on 7 October 2025.
Seventeen UCI WorldTeams and seven UCI ProTeams made up the twenty-four teams that participated in the race.
UCI WorldTeams
UCI ProTeams