The 2025 South Dakota State Jackrabbits football team represented South Dakota State University during the 2025 NCAA Division I FCS football season, as a member of the Missouri Valley Football Conference (MVFC). They were led by first-year head coach Dan Jackson who joins the program after working at Idaho as the team's defensive coordinator. He is replacing former coach Jimmy Rogers who left the program to be the head coach at Washington State. Jackson is assisted by first year offensive coordinator Eric Eidsness and defensive coordinator Brian Bergstrom. The Jacks played home games at Dana J. Dykhouse Stadium in Brookings, South Dakota.
The South Dakota State Jackrabbits drew an average home attendance of 17,640, the 8th-highest of all NCAA Division I FCS football teams.
The Missouri Valley Football Conference released its preseason poll on July 21, 2025, voted on by league athletic directors, coaches, and media members. The Jackrabbits were predicted to finish second in the conference.