The 2025 South Dakota Coyotes football team represented the University of South Dakota as a member of the Missouri Valley Football Conference (MVFC) during the 2025 NCAA Division I FCS football season. The Coyotes were led by first-year head coach Travis Johansen, who replaces former coach Bob Nielson who retired after the 2024 season. Johansen was promoted from being the Coyotes defensive coordinator last season, and was assisted by first year offensive coordinator Tim Morrison and first year defensive coordinator Billy Kirch. Morrison was also promoted within the program, as he was the Coyotes tight ends coach in 2024. Kirch joined the program after coaching at NAIA Northwestern University in Iowa for ten seasons.
The Missouri Valley Football Conference released its preseason poll on July 21, 2025, voted on by league athletic directors, coaches, and media members. The Coyotes were predicted to finish third in the conference.
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