The 2025 South Alabama Jaguars football team represented the University of South Alabama as a member of the Sun Belt Conference during the 2025 NCAA Division I FBS football season. They were led by second-year head coach Major Applewhite and played their home games at Hancock Whitney Stadium in Mobile, Alabama.
In the Sun Belt preseason coaches' poll, the Jaguars were picked to finish fourth place in the West division.
Linebacker Blayne Myrick was named the Preseason Defensive Player of the Year. Running back Kentrell Bullock and linebacker Blayne Myrick were awarded to be in the preseason All-Sun Belt first team offense and defense, respectively. Offensive lineman Jordan Davis, defensive back Wesley Miller and punter Aleksi Pulkkinen were named to the second team offense, defense and special teams.
The football schedule was announced on February 28, 2025.
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