The 2025 Savannah Challenger was a professional tennis tournament played on clay courts. It was the 15th edition of the tournament which was part of the 2025 ATP Challenger Tour. It took place in Savannah, Georgia, United States between April 21 and April 27, 2025.
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser: