The 2025 Portland State Vikings football team represented Portland State University as a member of the Big Sky Conference during the 2025 NCAA Division I FCS football season. The Vikings were led by eleventh-year head coach Bruce Barnum and played at the Hillsboro Stadium in Hillsboro, Oregon.
The Big Sky Conference released its preseason prediction poll on July 17, 2025. The Vikings were predicted to finish 10th in the conference.