The 2025 Mexican Softball League season was the second season of the Mexican Softball League (LMS). It was contested by eight teams. Two new clubs joined the league for the 2025 season: the Algodoneras de Unión Laguna, the softball section of Unión Laguna of the Mexican League, and the Naranjeras de Hermosillo, the softball section of Hermosillo of the Mexican Pacific League (LMP), marking the first LMP team to join the league.
The season started on 23 January and ended on 21 March. Diablos Rojos del México won the championship by sweeping the Sultanes de Monterrey in three games during the Serie de la Reina, the LMS championship series. Jazmyn Jackson, infielder for the Diablos, won the MVP award of the final series.