The 2025 Louisville Cardinals baseball team represented the University of Louisville during the 2025 NCAA Division I baseball season. The Cardinals played their home games at Jim Patterson Stadium as a member of the Atlantic Coast Conference. They were led by head coach Dan McDonnell, in his 19th year at Louisville.
For the first time since 2022, Louisville received a bid to play in the NCAA Tournament. The Cardinals received the 2 seed in the Nashville Regional hosted by the No. 1 overall seed Vanderbilt Commodores. Louisville swept the regional and advanced to host the Louisville Super Regional against the Miami Hurricanes. Louisville won the series 2âÂÂ1 and advanced to the 2025 Men's College World Series for the programs sixth appearance and first since 2019. Louisville advanced to the national semifinals where they lost to Coastal Carolina.
The 2024 Louisville Cardinals baseball team finished the season 32âÂÂ24, missing the NCAA Tournament for a second straight season and the third time in four years.
The Cardinals had only two players drafted in the 2024 MLB draft for its lowest total since the 2011 MLB draft. This was the first draft under coach Dan McDonnell that a player was not taken in the first 10 rounds. <br>
! style="background:#CC0000;color:white;"| Regular season ! colspan=9 | |- valign="top"
|- bgcolor="#bbffbb" | February 14 || 8:00 p.m. || FloSports || No. 19 Texas || || Globe Life Field<br><small>Arlington, TX</small>|| W 4âÂÂ3 || Biven (1âÂÂ0) || Mercer (0âÂÂ1) || || 8,344 || 1âÂÂ0 || âÂÂ
|- ! style="background:#CC0000;color:white;"| Postseason |-
|- bgcolor="#ffbbbb" | May 20 || 5:00 p.m. || ACCN || Pittsburgh || || Truist Field<br><small>Charlotte, NC</small> || L 11âÂÂ13 || Firoved (3âÂÂ4) || Cutts (3âÂÂ1) || None || 2,348 || 35âÂÂ21 || 0âÂÂ1
|- bgcolor="#bbffbb" | May 30 || 2:00 p.m. || ESPN+ || (3) East Tennessee State || || Hawkins Field<br><small>Nashville, TN</small>|| W 8âÂÂ3 || Forbes (3âÂÂ2) || Fink (6âÂÂ5) || Cutts (1) || 3,303 || 36âÂÂ21 || 1âÂÂ0 |- bgcolor="#bbffbb" | May 31 || 9:00 p.m. || ESPN2 || (1) No. 2 Vanderbilt || || Hawkins Field<br><small>Nashville, TN</small>|| W 3âÂÂ2 || West (2âÂÂ2) || Bowker (3âÂÂ5) || Schweitzer (1) || 3,802 || 37âÂÂ21 || 2âÂÂ0 |- bgcolor="#bbffbb" | June 1 || 9:00 p.m. || ACCN || (4) Wright State || || Hawkins Field<br><small>Nashville, TN</small>|| W 6âÂÂ0 || Eberle (6âÂÂ2) || Lax (5âÂÂ2) || Danilowicz (1) || 3,210 || 38âÂÂ21 || 3âÂÂ0
|- bgcolor="#bbffbb" | June 6 || 3:00 p.m. || ESPN2 || Miami || || Jim Patterson Stadium<br><small>Louisville, KY</small>|| W 8âÂÂ1 || Forbes (4âÂÂ2) || Ciscar (6âÂÂ2) || None || 5,776 || 39âÂÂ21 || 4âÂÂ0 |- bgcolor="#ffbbbb" | June 7 || 11:00 a.m. || ESPN || Miami || || Jim Patterson Stadium<br><small>Louisville, KY</small>|| L 6âÂÂ9 || Fischer (5âÂÂ1) || Brown (5âÂÂ5) || Walters (1) || 6,066 || 39âÂÂ22 || 4âÂÂ1 |- bgcolor="#bbffbb" | June 8 || 12:00 p.m. || ESPN || Miami || || Jim Patterson Stadium<br><small>Louisville, KY</small>|| W 3âÂÂ2 || Schweitzer (4âÂÂ2) || Smith (3âÂÂ1) || Cutts (1) || 6,046 || 40âÂÂ22 || 5âÂÂ1
|- bgcolor="#ffbbbb" | June 13 || 7:00 p.m. || ESPN || (8) No. 8 Oregon State || || Charles Schwab Field Omaha<br><small>Omaha, NE</small>|| L 3âÂÂ4 || Oakes (5âÂÂ0) || Schweitzer (4âÂÂ3) || || 24,963 || 40âÂÂ23 || 5âÂÂ2 |- bgcolor="#bbffbb" | June 15 || 2:00 p.m. || ESPN || No. 21 Arizona || || Charles Schwab Field Omaha<br><small>Omaha, NE</small>|| W 8âÂÂ3 || Biven (4âÂÂ0) || Hicks (5âÂÂ2) || || 23,647 || 41âÂÂ23 || 6âÂÂ2 |- bgcolor= | June 17 || 2:00 p.m. || ESPN || (8) No. 8 Oregon State || || Charles Schwab Field Omaha<br><small>Omaha, NE</small>|| || || || || || ||
|- ! colspan=9 | Legend: = Win = Loss = Canceled<br>Bold = Louisville team member * Non-conference game