The 2025 Louisiana Ragin' Cajuns football team represented the University of Louisiana at Lafayette in the Sun Belt Conference's West Division during the 2025 NCAA Division I FBS football season. The Ragin' Cajuns were led by Michael Desormeaux in his fourth year as the head coach. The Ragin' Cajuns played their home games at Cajun Field, located in Lafayette, Louisiana.
In the Sun Belt preseason coaches' poll, the Ragin' Cajuns were picked to finish first place in the West division.
Defensive lineman Jordan Lawson and defensive back Tyree Skipper were awarded to be in the preseason All-Sun Belt first team defense, respectively. Running back Bill Davis, offensive linemen Jax Harrington and George Jackson and linebacker Cameron Whitfield were named to the second team offense and defense.